Case report use of valproate in kleine levin syndrome

The patient was born through a C section, normally and without any problems. However, drugs to reduce suffering do exist, and include valproate, an anticonvulsant agent, clonazepam and benzodiazepine, to reduce muscle jerks.

In few cases, there was an impaired development history in the form delayed speech, walking, or reading. Pathologic studies have revealed neuronal loss and fibrillary gliosis in the hypothalamus, infundibular nuclei, and severe spongiosis of the white matter [ 8 ].

Hypersomnia and hyperphagia were present in all, while two-third of patients also had social and sexual disinhibition 11 out of 15 patients.

Ann Indian Acad Neurol. Treatment involves medications with different effects, but there is no specific and effective therapy. He also had three episodes of fall, unresponsiveness and epileptiform discharge in EEG twice.

These patients show an elevated body mass index, which can predispose to association with comorbidities such as the sleep obstructive apnea syndrome. Studying all cases in the literature, Tambasco et al.

Further study has been taken with other medical drugs, but none are effective. Screening for inherited errors of metabolism also was negative.

This pathology predominantly manifests itself in teenagers, being more frequent among males. Effects of various drug therapies on Kleine-Levin syndrome: Structural brain imaging and evaluation of the cerebrospinal fluid CSF and serological inflammatory markers are unremarkable. To our knowledge, this type of conversion reaction following temporal lobectomy has not been previously reported.

Hyperphagia, hypersexuality and behavioral or cognitive alterations irritability, aggressiveness, mental confusion, and disorientation are signs and symptoms found in isolation or in conjunction among these patients. Hypersexuality is more frequent among men and appears to be predictive of a more prolonged disease [2,4,5].

These patients show an elevated body mass index, which can predispose to association with comorbidities such as the sleep obstructive apnea syndrome. Valproate was gradually tapered and stopped in January on insistence of patient and family with discussing its pros and cons.

The precipitating factors are found more easily at the first episode of the disorder, being much less frequent in subsequent episodes [2,4]. For example, some case reports have implicated atypical antipsychotics in serotonin syndrome, but it appears based on their pharmacology that they are unlikely to cause the syndrome.

Treatment relies solely on evidence of case reports. Spells would lead to massive release of plasmatic norepinephrine, explaining the partial response to clonidine and the frequent association of autonomic symptoms, such as pallor, hypertension, and bradycardia.

Introduction Central core temperature is tightly controlled by hypothalamic centers and sudden changes in body temperature are very uncommon [ 1 ].

Nonetheless, ACC may not be a sine qua non condition for diagnosis, as originally defined, and SPH should thus be the main core feature, even without other abnormalities [ 3 ].

Each episode is of brief duration varying from a week to 1—2 months and affected people are entirely asymptomatic between episodes. Considering these clinical signs and symptoms alongside the absence of ACC in nearly half of the patients, a simplified approach to diagnose this syndrome would be to simply document SPH and autonomic dysfunction, keeping in mind that exclusion of other possible diagnoses is of paramount importance.

Serotonin syndrome has been reported in patients of all ages, including the elderly, children, and even newborn infants due to in utero exposure. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract.

Sleep paralysis and cataplexy are not common. Some considered this disease to be a form of diencephalic epilepsy, and although hypothalamic hamartomas and other dysplastic lesions are a known cause of subcortical epilepsy [ 11 ], there is no consistent evidence that SS shares this pathophysiology.

Serotonin syndrome

He usually went to bed between 22 and If physical restraints are necessary for severe agitation they must be rapidly replaced with pharmacological sedation. Agitation Specific treatment for some symptoms may be required. The same principle applies to alcohol intoxication.

Serotonin syndrome: Wikis

In addition, he showed eventual somniloquy and high and constant snoring, without episodes of observed apnea. Many patients reported amnesia of the events that occurred during an attack. The first symptom of CJD is rapidly progressive dementia, leading to memory loss, personality changes, and hallucinations.

The first symptom of CJD is rapidly progressive dementia, leading to memory loss, personality changes, and hallucinations. Personal and Family Medical History Birth history in few individuals revealed long labor, hypoxia, premature, or postmature birth. Nearly one-third of patients improved spontaneously without any medication, while rest was given lithium, carbamazepine, methylamphetamine, dextroamphetamine, and modafinil.

An adult onset patient with Kleine-Levin Syndrome responding to Valproate.

Kleine–Levin syndrome: Etiology, diagnosis, and treatment

Sleep Med ; Epub ahead of print. A case of locked-in syndrome complicated by central deafness. Nat Clin Pract Neurol. Aug;4(8) Epub May Case report. J Neurosurg ; Kleine–Levin syndrome: report of two cases with onset of symptoms precipitated by head trauma. Harefuah Sethi S. Braham J. EEG study in a case of Kleine–Levin syndrome.

Kleine–Levin syndrome (KLS) is a rare disease characterized by recurrent episodes of hypersomnia and to various degrees, behavioral or cognitive disturbances, compulsive eating behavior, and hypersexuality. The disease predominantly affects adolescent males. Successful use of Valproate in Kleine Levin Syndrome: a case report and review of cases reported from India Abstract Kleine-Levin Syndrome (KLS) is characterized by recurrent episodes of hypersomnia and other symptoms and it is a really challenging for the physician, since its causes are not yet clear, and available treatment options are not.

Successful Use of Valproate in Kleine-Levin Syndrome: A Case Report and Review of Cases Reported from India.

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Case Report Thermoregulatory Instability in Childhood: Linking the Normal syndrome. Herein, we report the case of a -year-old girl with Shapiro s syndrome and unaec ted corpus callosum.

1. Introduction A striking response to lithium in Kleine-Levin syndrome, Frontiers in .

Case report use of valproate in kleine levin syndrome
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